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paraneoplastic cerebellar degeneration |
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paraneoplastic cerebellar degeneration,
the most common paraneoplastic syndrome affecting the brain, occurring most commonly with ovarian and breast carcinoma and Hodgkin's disease, characterized pathologically by severe loss of Purkinje's cells and clinically by insidious and progressive truncal and appendicular ataxia, dysarthria, nystagmus, and, occasionally, dementia. In some women with gynecologic or breast carcinoma, it is associated with an autoantibody (anti-Yo). Want to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit the webmaster's page for free fun content. |
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