paraneoplastic cerebellar degeneration (redirected from Paraneoplastic cerebellar syndrome)

paraneoplastic cerebellar degeneration,

the most common paraneoplastic syndrome affecting the brain, occurring most commonly with ovarian and breast carcinoma and Hodgkin's disease, characterized pathologically by severe loss of Purkinje's cells and clinically by insidious and progressive truncal and appendicular ataxia, dysarthria, nystagmus, and, occasionally, dementia. In some women with gynecologic or breast carcinoma, it is associated with an autoantibody (anti-Yo).