Papez circuit

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Pa·pez cir·cuit

a long circuitous conduction chain in the mammalian forebrain, leading from the hippocampus by way of the fornix to the mammillary body and thence returning to the hippocampus by way of, sequentially, the anterior thalamic nuclei, cingulate gyrus, and parahippocampal gyrus.


James W., U.S. anatomist, 1883-1958.
Papez circle - network of nerve fibers and centers.
Papez circuit - a long circuitous conduction chain in the mammalian forebrain.
Papez theory of emotions - theory that emotions are controlled by Papez circle.
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References in periodicals archive ?
In the study of fornix stimulation in AD patients, volume changes of fornix and mammillary bodies were highly correlated with hippocampal volume change after fornix stimulation,[7] which strongly suggests the critical role of Papez circuit in memory function regulation.
If we talked about the strengths of a woman's mind, we should mention her emotional memory, it is much stronger than that of a man's, and this is related to the Papez circuit.
Paul MacLean (1952) later added the amygdala, septum and prefrontal cortex to the Papez circuit and thus established the limbic system concept as is understood today.
The aim of the present study was to investigate the impact of DBS at three separate targets in the Papez circuit, including the anterior nucleus of thalamus (ANT), the entorhinal cortex (EC), and the fornix (FX), on cognitive behaviors in an Alzheimer's disease (AD) rat model.
As a major pathway of the limbic system, the Papez circuit plays a vital role in memory formation and storage.
Moreover, because the DBS and sham DBS groups showed no differences in the latency during the training session of MWM, it could be assumed that DBS of the Papez circuit may have a limited effect on the acquisition of spatial learning.
Stimulation of parts of the Papez circuit has been known to prompt effects on fear and anxiety levels due to its interconnectedness with the amygdala.
Previous animal and clinical case studies have shown that DBS of the Papez circuit may enhance spatial memory by various mechanisms.
Although the present study did not reveal the molecular mechanism of DBS, our results indicate that the Papez circuit should be considered as a structural underpinning of DBS for AD.