Panton-Valentine leukocidin


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Panton-Valentine leukocidin

A pore-forming toxin secreted by Staphylococcus aureus that has recently been associated with necrotising pneumonia. In vitro, PVL induces polymorphonuclear cell death by necrosis or by apoptosis, depending on the PVL concentration. PVL-induced apoptosis was associated with a rapid disruption of mitochondrial homeostasis and activation of caspase-9 and -3, suggesting that PVL-induced apoptosis is preferentially mediated by mitochondria.

Pan·ton-Val·en·tine leu·ko·ci·din

(pan'tŏn-val'ĕn-tīn lū'kŏ-sī'din)
A staphylococcal cytolytic toxin that can act on polymorphonuclear leukocytes.

Panton-Valentine leukocidin

a nonhemolytic toxin produced by Staphylococcus aureus which kills segmented neutrophils and macrophages.
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c) The spa type and presence or Panton-Valentine leukocidin (PVL) genes are indicated for each MRSA isolate.
Dufour P, Gillet Y, Bes M, et al (2002), Community-acquired methicillin-resistant Staphylococcus aureus infections in France: emergence of a single clone that produces Panton-Valentine leukocidin.
A geographic variant of the Staphylococcus aureus Panton-Valentine leukocidin toxin and the origin of community-associated methicillin-resistant S.
Community-acquired methicillin-resistant Staphylococcus aureus isolated in Switzerland contains the Panton-Valentine leukocidin or exfoliative toxin genes.
Association between Staphylococcus aureus strains carrying gene for Panton-Valentine leukocidin and highly lethal necrotising pneumonia in young immunocompetent patients.
Otto's group to be a candidate factor for increased virulence, suggesting it to be more important than Panton-Valentine leukocidin (PVL).
Two people are known to have died from Panton-Valentine Leukocidin (PVL) positive MRSA at the University Hospital of North Staffordshire.
Maribel Espaba died from Panton-Valentine Leukocidin (PVL)-producing MRSA after contracting the superbug at the University Hospital of North Staffordshire in Stoke-on-Trent.
A Health Protection Agency spokesman said: "Eight cases of Panton-Valentine Leukocidin (PVL)-positive community-associated MRSA have been identified among individuals in a hospital and their close household contacts in the West Midlands.
Panton-Valentine leukocidin (PVL) is a cytotoxin virulence factor associated with severe, rapidly progressive, systemic disease including soft tissue infections and necrotizing pneumonia.
In addition, 10 of 20 CA-MRSA isolates tested positive for the Panton-Valentine leukocidin (PVL) gene, which code for a known CA-SA virulence factor.
Community-acquired MRSA tends to be susceptible to those agents, but it often has genes for encoding Panton-Valentine leukocidin, which is the presumed virulence factor for its necrotizing ability, he said.