alitretinoin (redirected from Panretin)

alitretinoin /al·i·tret·i·noin/ (-tret´ĭ-noin″) a topical antineoplastic used in the treatment of AIDS-related cutaneous Kaposi's sarcoma.

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alitretinoin,

a second-generation retinoid.

indication It is used to treat the cutaneous lesions of Kaposi's sarcoma.

contraindications Known hypersensitivity and pregnancy prohibit this drug's use.

adverse effects Side effects include rash, stinging, warmth, redness, erythema, blistering, crusting, peeling, contact dermatitis, and pain at the site of application.

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alitretinoin

Panretin

Pharmacologic class: Second-generation retinoid

Therapeutic class: Topical antineoplastic

Pregnancy risk category D

Action

Binds to and activates intracellular retinoid receptor subtypes, regulating expression of genes that control cellular differentiation and proliferation

Availability

Topical gel: 0.1%

⊘Indications and dosages

➣ Treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma

Adults: Apply to lesions b.i.d., gradually increasing to t.i.d. or q.i.d. according to individual lesion tolerance

Contraindications

• Hypersensitivity to retinoids or other drug components

Precautions

Use cautiously in:
• photosensitivity
• concomitant use of insecticides containing diethyltoluamide (DEET)
• elderly patients
• pregnant or breastfeeding patients
• children.

Administration

• Apply generous amount of gel to affected area. Let dry for 3 to 5 minutes before covering with clothing.

Route	Onset	Peak	Duration
Topical	Unknown	Unknown	Unknown

Adverse reactions

CNS: paresthesia

Skin: rash, pruritus, exfoliative dermatitis, skin disorder at application site (such as abrasion, burning, blisters, excoriation, scab, cracking, crusting, drainage, eschar, fissure, oozing, peeling, redness, or swelling), edema

Other: pain, increased sensitivity to sunlight or sun lamps

Interactions

Drug-behaviors. DEET-containing insect repellents: increased adverse reactions to DEET

Patient monitoring

• Monitor patient for serious adverse effects, especially burns caused by exposure to sunlight or sun lamps.

Patient teaching

• Instruct patient to apply generous amount of gel to affected skin area and let dry for 3 to 5 minutes before covering area with clothing.
• Caution patient to avoid applying gel to mucous membranes or to normal skin surrounding lesions.
☞ Inform patient that drug increases sensitivity to sunlight and that exposure to sunlight or sun lamps (even through window glass or on a cloudy day) may cause serious burn of treated areas. Caution him to avoid such exposure.
• Tell patient to avoid insect repellents containing DEET during therapy.
• Emphasize importance of keeping all medical appointments so prescriber can check progress and monitor for unwanted drug effects.
• As appropriate, review all other significant adverse reactions and interactions, especially those related to the behaviors mentioned above.