Paneth cells


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Related to Paneth cells: Peyer's patches

Paneth cells

(pah′nĕt)
[Josef Paneth, Ger. physician, 1857–1890]
Large secretory cells containing coarse granules, found at the blind end of the crypts of Lieberkühn (the intestinal glands). They secrete lysozyme.

Paneth cells

the cells that occur at the bases of the CRYPTS OF LIEBERKUHN. They persist for only about two weeks and then disintegrate. It is thought that they remove ions of heavy metal and secrete AMINO ACIDS and LYSOZYME - an antibacterial enzyme which controls the number of bacteria in the gut. It is also possible that they secrete enzymes such as peptidases and lipases.
References in periodicals archive ?
Distorted crypt architecture is frequent, as is surface epithelial sloughing and Paneth cell metaplasia.
Normal mice have Paneth cells with apical secretory granules by postnatal day seven (P7) and lysomzyme by P 10, but a delay in maturation is seen in germfree mice in whom lysozyme becomes detectable only by P148.
Hooper agrees that the normal inhabitants of the gut may use Paneth cells and Ang4 to raise what she calls an "electric fence" to keep out competing microbes.
Pancreatic endoproteases and pancreatic secretory trypsin inhibitor immunoreactivity in human Paneth cells.
Methyl mercury in primates produces histologic abnormality of one intestinal cell line: Paneth cells are enlarged and packed with secretory granules (21), also specifically reported in autistic children (5).
Enterocytes: Presence versus loss of brush border, shape and height of enterocytes, intracytoplasmic vacuolation, presence of goblet cells or Paneth cells, denudation or damage of the surface enterocytes.
Long known as Paneth cells, these sentries inhabit tiny pits in the intestine called crypts.