Distorted crypt architecture is frequent, as is surface epithelial sloughing and Paneth cell
Normal mice have Paneth cells
with apical secretory granules by postnatal day seven (P7) and lysomzyme by P 10, but a delay in maturation is seen in germfree mice in whom lysozyme becomes detectable only by P148.
Hooper agrees that the normal inhabitants of the gut may use Paneth cells
and Ang4 to raise what she calls an "electric fence" to keep out competing microbes.
Pancreatic endoproteases and pancreatic secretory trypsin inhibitor immunoreactivity in human Paneth cells
Methyl mercury in primates produces histologic abnormality of one intestinal cell line: Paneth cells
are enlarged and packed with secretory granules (21), also specifically reported in autistic children (5).
Enterocytes: Presence versus loss of brush border, shape and height of enterocytes, intracytoplasmic vacuolation, presence of goblet cells or Paneth cells
, denudation or damage of the surface enterocytes.
Long known as Paneth cells
, these sentries inhabit tiny pits in the intestine called crypts.