Paired helical filaments | definition of paired helical filaments by Medical dictionary
paired helical filaments
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paired helical filaments Neuropathology Paired structures that are core constituents of the neurofibrillary tangles of Alzheimer's disease and occur in Down syndrome, Hallervorden-Spatz disease, lead encephalopathy, lipofuscinosis, subacute sclerosing panencephalitis, and tuberous sclerosis. See Alzheimer's disease, Neurofibrillary tangles, Senile plaques.
References in periodicals archive
Conformation of paired helical filaments
blocks dephosphorylation of epitopes shared with fetal tau except Seri 99/202 and Ser199/Thr205.
Typical AD neuropathological lesions include perikaryal neurofibrillary tangles, which consist of paired helical filaments
For example, the Htau mice develop paired helical filaments
, neurofibrillary tangles and, eventually, neuronal death.