In a 10-year retrospective review of ocular surface neoplasia, MMC was shown to have a highly effective role as primary therapy for PAM and CCIN and to be useful as an adjunctive to surgery with cryotherapy, brachytherapy for SCC, melanoma and SGC with pagetoid
Williamson JD, Colome MI, Sahin A, Ayala AG, MedeIros LJ: Pagetoid
Bowen disease: a report of 2 cases that express cytokeratin 7.
The various other clinico-pathologic features that indicate a worse prognosis are vascular, lymphatic and orbital invasion, poor differentiation, multicentric origin, duration of symptoms greater than 6 months, a highly infiltrative pattern and pagetoid
invasion of the overlying epithelia of the eye lids (4).
spread of CIS makes it impossible to guarantee that a negative FS ensures that CIS is not more proximal.
form of fibrous dysplasia may represent the end stage of sclerotic and cystic radiographic patterns.
Abstract: Clear cell squamous cell carcinoma in situ, also referred to as pagetoid
or clear cell Bowen disease, is a rare pathologic variant of this neoplasm.
4) These cortical insufficiency fractures are so named because they occur along the tensile (convex) surface of the weakened and often bowed pagetoid
bone, analogous to the site where the skin of a banana would break upon "snapping" it open.
Poor prognostic indicators of ocular lesions include tumor thickness, pagetoid
spread, and involvement of the cornea, episclera, palpebral conjunctiva or fornix.
A, Case 490 (SW0 negative): primary lesion showing atypical intraepidermal lentiginous proliferation of large melanoma cells with suprabasal pagetoid
spread (arrows) and extensive dermal infiltration I epithelioid cells with nuclear atypia and focal pigmentation (arrowheads).
Other indications include persistent inflammatory change, suspicion of an abscess, persistent bloody nipple discharge, Pagetoid
changes of the nipple, or axillary lymphadenopathy.
Variants of Spitz nevus Variants Reference Angiomatoid Spitz nevus (a) 2, 3 Atypical pigmented spindle cell nevus (b) 4, 5 Atypical Spitz nevus (c) 4, 5 Desmoplastic Spitz nevus (d) 6, 7 Hyalinizing Spitz nevus (e) 1 Malignant Spitz nevus (f) 5, 8 Pagetoid
Spitz nevus 5, 9 Pigmented spindle cell nevus 4, 10, 11 Recurrent Spitz nevus 12 Spitz nevus with florid pseudoepithelial 13 hyperplasia Spitz nevus with halo phenomenon 14 Tubular epithelioid cell nevus (g) 15 (a) Several investigators consider angiomatoid Spitz nevus to be a variant of desmoplastic Spitz nevus.
1 cm (Figure 2, B); and extension of underlying malignancy with 2 cases of pagetoid
spread of spatially remote invasive ductal carcinoma (IDC) along lactiferous ducts (Figure 2, C and D).