NLRP2

(redirected from PYPAF2)

NLRP2

A gene located on chromosome 19q13.42 that encodes a NLRP2 (i.e., NALP2), a pyrin-like protein involved in activating caspase-1 (CASP1) by Toll-like receptors. NALP2 suppresses TNF- and CD40-induced NFKB1 activity at the IKK complex by inhibiting TNF-induced NFKBIA degradation. When associated with PYCARD, NALP2 activates CASP1, leading to the secretion of the pro-inflammatory cytokine IL1B.
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