PUM1

PUM1

A gene on chromosome 1p35.2 that encodes a sequence-specific RNA-binding protein that regulates translation and mRNA stability by binding the 3'-UTR of mRNA targets. PUM1 may support stem cell proliferation and self-renewal by regulating translation of key transcripts. It is expressed in the brain, heart, kidneys, muscle, intestine and stomach and downregulated in keratinocytes in response to UVB irradiation.
References in periodicals archive ?
8] ([beta]-actin), PSMC4 (proteasome 26S subunit, ATPase, 4), PUM1 (pumilio homolog 1, Drosophila), MRPL19 (mitochondrial ribosomal protein L19), and SF3A1 (splicing factor 3a, subunit 1, 120 kDa)].
8] Human genes: ACTB, [beta]-actin; PSMC4, proteasome 26S subunit, ATPase, 4; PUM1, pumilio homolog 1, Drosophila; MRPL19, mitochondrial ribosomal protein L19; SF3A1, splicing factor 3a, subunit 1, 120 kDa; ERBB2, v-erb-b2 erythroblastic leukemia viral oncogen homolog 2; ESR1, estrogen receptor 1; ICBM, immunoglobulin binding protein 1.