PTHrP


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PTHrP

PTHrP

Abbreviation for parathyroid hormone-related peptide.
References in periodicals archive ?
Release of PTHrP comprises nearly 80% of hypercalcemia cases (malignancy-related humoral hypercalcemia) associated with malignancies (3), (12-14).
Studies in vivo with mice have not exposed accretion in the expression of Tax in these animals, suggesting that other factors influence the regulation of PTHrP.
3] y mas bien parecen deberse al incremento en la PTHrp durante las etapas tempranas de la gestacion, que estimula la resorcion osea en el esqueleto materno, o tambien a las bajas concentraciones de estrogenos en la gestacion temprana (22).
However, PTHrP is considered to be the major pathogenic factor (97-99) as the tumour burden and bone lesions have been shown to be decreased significantly by treatment with PTHrP-neutralizing antibody in mice inoculated with a human breast cancer cell line [MDA-MB-231] (100) or lung squamous cell carcinoma-derived cells [HARA] (101).
In the August JOURNAL OF INVESTIGATIVE DERMATOLOGY, Holick reports that in mice, injections of PTHrP blockers before chemotherapy increased the number of hairs that grew properly after chemotherapy.
Holick and his associates incubated keratinocytes with the PTHrp agonist parathyroid hormone (1-34) [PTH(1-34)], it inhibited cell proliferation and induced terminal differentiation.
The related PTHrP skin hormone's agonists, PTH (1-34) and PTHrP (1-34), are effective in stopping skin growth and creating differentiation found in patients with psoriasis.
4] PTHrP seems to play an important role in HM,[1,4-6] with characteristic clinical findings such as hypercalcemia, hypophosphatemia, reduction in %TRP, and an increase of urinary cyclic adenosine monophosphate.
Kisaca kemik kutle kaybi; primer olarak sut uretimi ile artan kalsiyum ihtiyaci ve ostrojen yetmezligi (laktasyon amenoresi) ile iliskili olup PTHrP de bu kayipta rol oynar.
Malignant hypercalcaemia is thought to arise from the secretion of PTHrP which is synthesised by tumour cells and has a similar action to parathyroid hormone.
This condition is physiologically (excessive production of PTHrP in placenta and/or mammary gland in pregnancy, puerperium, lactation) or milk-alkali syndrome (associated with intake of a large amount calcium and absorbable alkali) or malignant tumors (3).
RANK-ligand is secreted from the osteoblasts, after being upregulated by PTHrP and TGF-[beta], and attaches to the receptor RANK on osteoclast precursor cells.