PTHrP


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PTHrP

PTHrP

Abbreviation for parathyroid hormone-related peptide.
References in periodicals archive ?
Release of PTHrP comprises nearly 80% of hypercalcemia cases (malignancy-related humoral hypercalcemia) associated with malignancies (3), (12-14).
o] stimulates PTHrP production in both normal (103,104) and malignant cells (105,106).
In contrast, injections of a PTHrP mimic shunted hair follicles into catagen, making them more sensitive to chemotherapy.
In addition, PTHrP has been detected in prostate cancer cells.
The C-terminal PTH was 53 pg/mL (70 to 270 pg/mL), intact parathyroid hormone (PTH) was 6 pg/mL (10 to 65 pg/mL), PTHrP was less than 0.
Papers examine the role of Vitamin D and its analogs, TGF-B and IGF, immune-cell- derived matrix metalloprotein, osteopontin, Interlukin-11, PTHrP and antithrombotics in tumor progression and metastasis.
Further, this inhibition of PTHrP is associated with accelerated skeletal maturity.
When made by the cancer cells, PTHrP carries out its normal role of stimulating bone growth.
The bone anabolic candidate BA058, a PTHrP (parathyroid hormone-related protein) analogue is currently in Phase II clinical studies conducted by Radius for the treatment of osteoporosis.
5 /PRNewswire/ -- Radius Health ("Radius") today announced topline Phase 2 data demonstrating that in women with osteoporosis, BA058 -- the company's novel PTHrP (parathyroid hormone-related protein) analog -- significantly increased bone mineral density (BMD) at the lumbar spine and femoral neck (a common fracture site located in the hip joint) after six months of therapy.