DLG4

(redirected from PSD95)

DLG4

A gene on chromosome 17p13.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family that forms a complex with another MAGUK, DLG2, and is recruited into NMDA receptor and potassium channel clusters. DLG2 and DLG4 may interact at postsynaptic sites to form a multimeric scaffold for clustering of receptors, ion channels and signalling proteins.
References in periodicals archive ?
The PSD95 inhibitor published by the Toronto team acts to protect the brain by preventing the occurrence of these neurotoxic reactions.
Animals that were treated with the PSD95 inhibitor after a stroke had greatly reduced brain damage and this translated to a preservation of neurological function.
Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons.
We also observed no significant change in levels of the major synaptic proteins synaptophysin (presynaptic) and PSD95 (postsynaptic) (Figure 2C, D), consistent with the normal histological appearance of hippocampal neuron layers (data not shown).