DLG4

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DLG4

A gene on chromosome 17p13.1 that encodes a member of the membrane-associated guanylate kinase (MAGUK) family that forms a complex with another MAGUK, DLG2, and is recruited into NMDA receptor and potassium channel clusters. DLG2 and DLG4 may interact at postsynaptic sites to form a multimeric scaffold for clustering of receptors, ion channels and signalling proteins.
References in periodicals archive ?
20) PSD95 comprises three PDZ domains, one GK domain, and one SH3 domain.
2006) Rapid redistribution of synaptic PSD95 in the neocortex in vivo.
The GluN2B-to-GluN2A shift does not occur in knockout mice that do not express PSD95 (Belque et at.
As SAP102 is replaced by PSD95, G1uN2B is replaced by G1uN2A (Sans et al.
La PSD95 une los receptores de glutamato N-Metil-D-Aspartato (NMDA) a la nNOS, lo que lleva a la produccion de oxido nitrico (NO).
CAPON: a protein associated with neuronal nitric oxide synthase that regulates its interactions with PSD95.
The PSD95 inhibitor published by the Toronto team acts to protect the brain by preventing the occurrence of these neurotoxic reactions.
Animals that were treated with the PSD95 inhibitor after a stroke had greatly reduced brain damage and this translated to a preservation of neurological function.
Coincidence in dendritic clustering and synaptic targeting of homer proteins and NMDA receptor complex proteins NR2B and PSD95 during development of cultured hippocampal neurons.
Our previous study [sup][14],[15] has also shown that cognitive impairment present in 5xFAD mice was accompanied by structural degradation of synapses and decreased expression of synaptophysin and PSD95 in the brain at the age of 6–7 months.
17,32) In the brain, neddylation of PSD95 is essential for formation and maintenance of spines in the excitatory synapses, (26) although the detailed mechanism is not known.
We also observed no significant change in levels of the major synaptic proteins synaptophysin (presynaptic) and PSD95 (postsynaptic) (Figure 2C, D), consistent with the normal histological appearance of hippocampal neuron layers (data not shown).