BRCA1

(redirected from PSCP)
Also found in: Dictionary, Acronyms.
Related to PSCP: Public Service Commission

BRCA1

symbol for a breast cancer gene. BRCA1 is a tumor suppressor gene. A healthy BRCA1 gene produces a protein that protects against unwanted cell growth. The protein is packaged by the cell's Golgi apparatus into secretory vesicles, which release their contents on the cell's surface. The protein circulates in the intracellular space, attaching itself to neighboring cell receptors. The receptors signal the cell nuclei to stop growing. When the gene is defective, it produces a faulty protein that is unable to prevent proliferation of abnormal cells as they evolve into potentially deadly breast cancer. BRCA1 may also normally inhibit ovarian cancer.

BRCA1

A gene on chromosome 17q21, which encodes a protein that plays a role in maintaining genomic stability and acts as a tumour suppressor. It combines with other tumour suppressors, DNA damage sensors and signal transducers to form a large multi-subunit-protein complex known as the BRCA1-associated genome surveillance complex (BASC), which associates with RNA polymerase II and histone deacetylase complexes, thus playing a role in transcription, DNA repair of double-stranded breaks and recombination. BRCA1 mutations cause 40% of inherited breast cancers and over 80% of inherited breast and ovarian cancers.

BRCA1

Molecular oncology A large tumor suppressor gene on chromosome 17 which is linked to breast, ovarian, prostate and other CAs; Pts with BRCA1 represent 5% of all breast CAs; ♀ with BRCA1 have an 85% chance of developing breast CA before age 65; mutations of BRCA1 are common in Ashkenazi Jews Lab BRCA1 and BRCA2 are part of some commercial diagnostic labs' genetic services. See Tumor suppressor gene.
References in periodicals archive ?
Residents throughout Southeastern Pennsylvania rely on PSCP for information and referrals for mental health and addiction services," said Diehl.
The transfer of the 241,000 units of PSCP from CMP to CDS was effected through the entering into by these parties of a unit transfer agreement dated August 29, 2003 (the "Agreement").
The next PSCP Steering Committee meeting will be at the Congress of Cities in San Antonio, on Wednesday, November 11.
Details: For more information on the PSCP Committee contact Mitch Herckis at Herckis@nlc.
31, 1998, will be paid only to those Qualifying Persons who have exchanged their units in Old PSCP and PSCP IV for Units in the Partnership.
The PSCP committee concluded its meeting with a review of policy amendments and resolutions for 2009.
The PSCP Steering Committee will meet again September 4-6 in Farmington Hills, Mich.
The PSCP committee focused its attention on addressing how the federal government can assist municipalities in addressing local challenges related to violent crime and disaster preparedness and response.
PSI, organized in 1972, has been engaged, directly and through subsidiaries, in the acquisition, development, construction and operation of mini-warehouses and, to a lesser extent, other commercial properties, PSMI, PSCP and the Adviser are subsidiaries of PSI.
The steering committee wrapped up its work on the 2007 policy process, recommending nine existing resolutions for renewal and referring two new resolutions to the PSCP Policy and Advocacy Committee for discussion and approval at the Congress of Cities in New Orleans on November 14.
PSCP was joined at this meeting by the steering committee of the Central Cities Council.
Agile), the technology leader in tunable wireless components, today announced its PSCPS family of coplanar analog phase shifters.