15) PSA density (adjusted for prostate volume determined by ultrasound) can improve test accuracy at intermediate PSA levels, (16) and PSA velocity
, change in PSA level over time, has also been examined to differentiate tumor from benign disease.
9] and it can be complemented with parameters, such as PSA velocity
We think that we've seen a leveling of overdetection, but I think we'll see another round of overdetection, because of a lowering PSA threshold to prompt biopsy; aggressive rescreening, the use of PSA velocity
at low PSA values to prompt biopsy, and the use of saturation biopsies," he said during the conference, sponsored by the American Association for Cancer Research and the Prostate Cancer Foundation.
3) Additionally, though not an absolute criteria for or against malignancy, PSA velocity
can serve as a gauge regarding the likelihood of a malignant condition.
Unpredictable remission and kinetic characteristics may complicate use of PSA velocity
following RP for prediction of long-term recurrence.
Relapse after radical prostatectomy correlates with preoperative PSA velocity
and tumor volume: results from a screening population.
1992) first reported that a PSA velocity
Washington, Apr 10 (ANI): Change in PSA levels over time, known as PSA velocity
, is a poor predictor of prostate cancer and may lead to many unnecessary biopsies, according to researchers at Memorial Sloan-Kettering Cancer Center.
The new research shows that PSA velocity
as well as the marker's level in the blood, is an unreliable predictor of prostate cancer.
In secondary subgroup analysis, among men in the highest quartile of baseline plasma selenium, mean PSA velocity
was significantly higher in those receiving 800 mcg per day of selenium than in those receiving placebo (p = 0.
Eric Klein of the Glickman Urological and Kidney Institute who says the "data suggesting that a baseline PSA in men in their 40s and subsequent PSA velocity
(the rate of increase in PSA levels) can predict both lifetime risk of developing cancer and potentially lethal cancers.
Nine patients showed decreases in PSA velocity
, suggesting that even at this late stage, both vaccine regimens were capable of inducing T-cell responses to the tumors.