In my view, not only would a therapy that can increase PSADT in a majority of patients obviously be extremely valuable in the therapeutic sense, but there is the possibility that monitoring PSADT can help identify patients that may require additional more aggressive treatment regimens due to inability to decrease PSA velocity
Postoperative PSA and PSA velocity
identify presence of prostate cancer after various surgical interventions for benign prostatic hyperplasia.
2) Several PSA derivatives, including free PSA (fPSA), percentage of free-to-total PSA ratio (%fPSA), PSA density (PSAD), and PSA velocity
(PSAV) have made a major improvement in patient selection for prostate biopsy.
Hence, there is a need of estimation and interpretation of different PSA forms like free PSA levels, prostatic density, PSA velocity
In the literature, although PSA velocity
(PSAV) is statistically associated with outcomes of definite PCa in first or repeat prostate biopsies,[sup],, it adds little extra value to PSA itself for PCa detection.
15) PSA density (adjusted for prostate volume determined by ultrasound) can improve test accuracy at intermediate PSA levels, (16) and PSA velocity
, change in PSA level over time, has also been examined to differentiate tumor from benign disease.
9] and it can be complemented with parameters, such as PSA velocity
We think that we've seen a leveling of overdetection, but I think we'll see another round of overdetection, because of a lowering PSA threshold to prompt biopsy; aggressive rescreening, the use of PSA velocity
at low PSA values to prompt biopsy, and the use of saturation biopsies," he said during the conference, sponsored by the American Association for Cancer Research and the Prostate Cancer Foundation.
Men in the study had a PSA greater than 4 ng/mL and/or a suspicious digital rectal examination and/or a PSA velocity
(PSAV) of greater than 0.
Another PSA derivative of feasible importance is PSA velocity
(PSAV), though the available data are also quite controversial.
3) Additionally, though not an absolute criteria for or against malignancy, PSA velocity
can serve as a gauge regarding the likelihood of a malignant condition.
Unpredictable remission and kinetic characteristics may complicate use of PSA velocity
following RP for prediction of long-term recurrence.