PSA


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PSA

Abbreviation for prostate-specific antigen.

PSA

prostate-specific antigen.

PSA

abbr.
1. prostate-specific antigen
2. public service announcement

PSA

1 abbreviation for pressure-sensitive adhesive.
2 abbreviation for prostate-specific antigen.

PSA

Prostate-specific antigen. A 34-kD glycoprotein serine protease (formally, kallikrein-related peptidase 3) encoded by KLK3 on chromosome 19q13.41, which has significant homology with other neutral proteases. It is secreted exclusively by the prostate epithelium and is responsible for lysing the seminal coagulum; it is present in the serum and is increased in patients with both benign (acute inflammation and BPH) and malignant (cancer) prostate lesions;. Most serum PSA is bound to protease inhibitors, including alpha1-antichymotrypin (the form usually measured in the lab), alpha1-macroglobulin, and in far lower amounts to alpha1-antitrypsin; small amounts of PSA in the circulation are not bound—i.e., free—to a carrier protein. Prostate cancer is present in 22% of those with PSA levels above 4.0 µg/L, and 60% of those with levels above 10 µg/L.

PSA

Prostate-specific antigen Urology A 34 kD glycoprotein serine protease with significant homology with other neutral proteases; PSA is secreted exclusively by the prostate epithelium and is responsible for lysing the seminal coagulum; it is present in the serum and is ↑ in Pts with both benign–acute inflammation and BPH and malignant–CA prostate lesions; most serum PSA is bound to protease inhibitors, including α1-antichymotrypin–the form usually measured in the lab, α1-macroglobulin, and in far lower amounts to α1-antitrypsin; small amounts of PSA in the circulation are not bound–ie, free—to a carrier protein; prostate CA is present in 22% of those with PSA levels above 4.0 µg/L, 60% of those with levels above 10 µg/L

PSA

Abbreviation for prostate-specific antigen.

PSA

See PROSTATE-SPECIFIC ANTIGEN.

PSA (Prostate specific antigen)

A tumor marker associated with prostate cancer.
Mentioned in: Tumor Markers

Patient discussion about PSA

Q. Would kidney stones affect a PSA reading? Would drinking lots of grapefruit juice affect a PSA reading? My husband's PSA reading jumped from a 4.2 to a 17 in @ 2 years' time. How can that be? This man takes all sorts of supplements and really watches his diet. He also takes good care of his body, and does NOT look or act 68.

A. You should get your parathyroid gland checked out. Your calcium level might be causing the kidney stones.

Q. Rising PSA to 10 with two negative biospies? Expect cancer? 67 yrs old in good health otherwise.

A. High values don't always mean it's cancer. At 67 years old, you're prostate is most likely enlarging, resulting in the higher PSA results. And after two negative biopsies, it sounds like you're in the clear. Like Brandon said though, keep up with your regular check ups.
Source: http://www.northshore.org/healthresources/encyclopedia/encyclopedia.aspx?Version=Q3_08&DocumentHwid=hw5522&ViewHwid=hw5548

More discussions about PSA
References in periodicals archive ?
Samadi, "The controversy over PSA screening exposes the importance of the need for physicians to put more emphasis on treating their patients as individuals, and not just as a population.
The key to better diagnosis of prostate cancer is finding more effective ways to use PSA as a screening tool--ultimately, making PSA a better prostate cancer detection tool in the modestly-elevated PSA range.
Thus, our results from this study confirmed an observation that the 90:10 PSA Stanford/WHO reference standard appears to be composed of approximately 85% PSA-ACT and 15% free PSA, not 90% PSA-ACT and 10% free PSA.
In the second study, 180 men aged 24-88 years had total PSA levels of 2.
With current assays for PSA, the actual amount of t-PSA is underestimated.
This potential must be recognized, as only 36% to 48% of patients will experience a prostate-specific antigen (PSA) response (defined as a reduction in serum PSA of at least 50%) with this therapy.
Anti-PSA antibodies show different reactivities and affinities for the various forms of free PSA and PSA-ACT in buffer- or serum-based samples.
There is no convincing evidence yet that treating prostate cancer in men with PSA levels below 4 ng/mL will produce better outcomes than reserving treatment for higher PSA levels, he added.
Meanwhile, researchers at the Johns Hopkins Medical Institutions in Baltimore and the Fox Chase Cancer Center in Philadelphia are pursuing a prostate cancer test that is even less invasive than PSA blood tests.
In one such study of nearly 1,000 breast cancer patients, women who had higher levels of PSA had a better prognosis in terms of both recurrence and survival than women with lower levels, additional evidence PSA may possess some tumor-fighting qualities.
com will provide PSA Directors with the convenience and ease of downloading PSAs right from their desktops.