PSEN1

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PSEN1

A gene on chromosome 14q24.3 that encodes a probable catalytic subunit of the gamma-secretase complex, which catalyses the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP. It may play a role in intracellular signalling and gene expression, and in linking chromatin to the nuclear membrane. PSEN1 stimulates cell–cell adhesion by associating with the E-cadherin/catenin complex; it cleaves E-cadherin during apoptosis or calcium influx, promoting the disassembly of the E-cadherin/catenin complex and increases the pool of cytoplasmic beta-catenin, thus downregulating Wnt signalling. It may play a role in haematopoiesis.

Molecular pathology
Defects in PSEN1 cause of Alzheimer disease type 3, frontotemporal dementia, cardiomyopathy dilated type 1U, and familial acne inversa type 3.
References in periodicals archive ?
Six Beef Quarter Pounders (681g), Tesco, PS4 or two for PS7 SAVE: PS1
Mr Kipling Choc& Slime Slices (6), PS1, Sainsbury's
Prize list:-Limousin bullock - 1st Nuncleugh PS1,230, 2nd Nunscleugh PS1,235, 3rd Dumbretton PS1,220.
On tree: White lights PS1, bright butterflies PS1 for four, two-pack bright sequin baubles PS1 for two, bright mirror baubles PS1 for three, tree topper PS1, four-pack bright swirl baubles PS1, gold crown decorations PS1 for two, gold poinsettia clips PS1 for four, baubles with sequins PS1 for two, all Poundland.
Milkybar Ghost (25g), Sainsbury's, 65p or two for PS1 SAVE: 30p
PRINCIPAL PRICES BULLOCKS Angus PS1,265, PS1,245 Roanstree, PS1,245 The Green, PS1,200 (x6) Sandbed, PS1,200 Rigg Smiddy, PS1,170 (x4) Sandbed, PS1,130 Roanstree, PS1,090, PS1,075 (x2) The Green, PS1,010 Westwinds, PS1,000 Sandbed and Westwinds, PS970 Westwinds, PS960 Rigg Smiddy.
HOW ICES 2008 Magnum Classic Twister 70p Wall's Feast Cadbury Flake Cone Calippo Orange Cornetto Strawberry Solero Exotic Magnum White A Wall's Feast has increased from 70p to PS1.
Their run of 66 in calf cows, aged 1998-2012 averaged PS1,602 with the bulls making PS3,600 for the 3 year old and the 7 year old made PS3,100.
30 are on a buy one, get one free deal, while Walkers multipacks (6x25g) in a variety of flavours are PS1.
Rushmoor PS1,984, Walsall PS1,892, Sutton PS1,865, Sandwell PS1,837, Bexley PS1,836, Wolverhampton PS1,811, Barnet PS1,798, Merton PS1,786, Ipswich PS1,743, Bristol PS1,675, Coventry PS1,661, Sefton PS1,655, Spelthorne PS1,648, and Kingston upon Thames 1,635.
Top prices Hoggets (p/kg) - D Pierce, Bryn Deunydd; Heifers (p/kg) - Jones Bros, Cae''r Weirglodd; Steers (p/kg) & PS1,780.