PRPP synthetase | definition of PRPP synthetase by Medical dictionary
PRPP syn·the·tase (sin'the-tās),
An enzyme that catalyzes the reaction of α-d-ribose 5-phosphate and ATP to produce PRPP and AMP; a regulatory enzyme in purine and pyrimidine biosynthesis; enhanced activity of this enzyme results in an increase in purine biosynthesis leading to gout.
References in periodicals archive
The four mutations identified in the PRPS1 gene cause a decrease in the production of the PRPP synthetase 1 protein that results in defects in sensory cells (called hair cells) in the inner ear, and eventually leads to progressive deafness.
Our findings emphasize the body's need for tight regulation of PRPP synthetase 1 since a drop in activity can lead to deafness.