STK10

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STK10

A gene on chromosome 5q35.1 that encodes a serine/threonine-protein kinase involved regulating lymphocyte migration by phosphorylating ERM proteins such as MSN and possibly PLK1. It downregulates MAP3K1/MEKK1 and may regulate the cell cycle by acting as a polo kinase kinase.

Molecular pathology
Defects in STK10 have been linked to testicular germ cell tumour.