PRKCA

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PRKCA

A gene on chromosome 17q22-q23.2 that encodes a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase, which up- or downregulates cell proliferation, apoptosis, differentiation, migration and adhesion; tumourigenesis; cardiac hypertrophy; angiogenesis; and platelet function and inflammation, by directly phosphorylating targets such as RAF1, BCL2, CSPG4, TNNT2/CTNT, or activating signalling cascades involving MAPK1/3 and RAP1GA.
References in periodicals archive ?
During the third quarter of 2015, we presented preclinical data validating the advancement of BLU-554 into clinical development and identifying PRKACA as a novel target for therapeutic intervention.
The new data highlight the role of PRKACA in FL-HCC and its potential as a novel target for therapeutic intervention.
Novel Drug Target for FL-HCC Using a proprietary computational approach to identify kinase fusions as drivers of cancer, Blueprint Medicines scientists discovered a recurrent DNAJB1-PRKACA fusion in FL-HCC tumors that causes increased signaling of the PRKACA kinase.