PKN2

(redirected from PRK2)

PKN2

A gene on chromosome 1p22.2 that encodes a ubiquitous PKC-related serine/threonine-protein kinase and Rho/Rac effector protein which participates in specific signal transduction pathways. It plays a role regulating cell cycle progression, actin cytoskeleton assembly, cell migration, cell adhesion, tumour cell invasion and transcription activation.
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The treatment of liver cell lines (stably replicating HCV sub-genomic replicon) with these inhibitors cleared viral RNA suggesting that PRK2 inhibitors act by suppressing HCV replication via inhibition of NS5B activity (118).