PRDM1

PRDM1

A gene on chromosome 6q21 that encodes a protein which represses beta-interferon gene expression, by binding to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. PRDM1 transcription increases in response to viral induction.
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3 which contained CDKN2A and CDKN2B genes, and they found that deletion of 6q21 ( PRDM1 ) was associated with shorter OS.
Mutational analysis of PRDM1 indicates a tumor-suppressor role in diffuse large B-cell lymphomas.
A large scale replication study confirmed some of these associations and identified TNIP1 PRDM1 JAZF1 UHRF1BP1 and IL10 as risk loci for SLE (Gateva et al 2009).
A large scale replication study identifies TNIP1 PRDM1 JAZF1 UH-RF1BP1 and IL10 as risk loci for systemic lupus erythema-tosus.
Cells with the protective version of both markers expressed PRDM1 after being exposed to radiation.
Previous studies have found that PRDM1 is involved in a variety of fundamental cellular processes, including proliferation, differentiation and apoptosis -- which can all go awry in cancer.