SERPINH1

(redirected from PPROM)
Also found in: Acronyms.

SERPINH1

A gene on chromosome 11q13.5 that encodes a member of the serpin superfamily of serine proteinase inhibitors that localises to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone.

Molecular pathology
Anti-SERPINH1 autoantibodies occur in patients with rheumatoid arthritis. SERPINH1 expression may be a marker for cancer. Nucleotide polymorphisms may be linked to pre-term labour due to premature rupture of membranes.
References in periodicals archive ?
It was found that among PPROM subjects, bacteria counts were highest compared to all other groups at both the rupture site and distant from the rupture site.
Because of the high incidence of PPROM in this study post-radical trachelectomy pregnancies should be treated as high risk, he said.
Tripp Nelson of the Medical University of South Carolina, Charleston, found that malpresentation, bleeding, and sexually transmitted infection each predicted emergent outcomes in PPROM patients.
One of the main findings of this study suggests that within our population, group B streptococcus appears to be the primary causal agent associated with PPROM.
Cause of intrauterine deaths at 28 weeks, gestation or later <P75 P75-P95 >P95 AREDF Resistance index 0 0 0 2 Pre-eclampsia/GR 1 1 1 2 GR 1 0 0 0 Syphilis/GR 3 0 0 0 Diabetes 1 0 0 0 Congenital abnormalities 1 2 0 0 Abruption 0 1 0 0 Infection/PPROM 3 2 0 0 Unknown 10 6 1 4 <P75 = less than 75th percentile for gestational age; P75-P95 = between 75th and 95th percentile; >P95 = above 95th percentile; GR = growth restriction; PPROM = preterm prelabour rupture of membranes; AREDF = absent/reversed end-diastolic flow.
The findings contrast with those from several prior studies, which suggested a link between LEEP and preterm birth, particularly preterm birth secondary to PPROM, he said.
A woman with appropriate cultures showing that she is GBS negative, for example, does not need prophylaxis -even if she presents with PPROM.
He and his associates compared delivery records and NICU data on singleton pregnancies with PPROM delivered between 32 weeks and 36 weeks, 6 days of gestation at their institution from November 2003 through June 2009.
The investigators studied 430 pregnancies in 1998-2000 with PPROM and 24-36 weeks' gestation to determine optimal delivery time.
It's hard to differentiate preterm labor with or without PPROM," Dr.
When used to measure human chorionic gonadotropin in cervical washings of 52 women with PPROM, the method demonstrated a 95% positive predictive value, Dr.
Antibiotics have been used routinely after PPROM since a study by the Maternal-Fetal Medicine Units Network of the National Institute of Child Health and Human Development conducted a trial in which 614 women without cerclage were randomized to receive intravenous ampicillin and erythromycin for 48 hours, followed by oral amoxicillin and erythromycin for 5 days, or a placebo.