SERPINH1

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SERPINH1

A gene on chromosome 11q13.5 that encodes a member of the serpin superfamily of serine proteinase inhibitors that localises to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone.

Molecular pathology
Anti-SERPINH1 autoantibodies occur in patients with rheumatoid arthritis. SERPINH1 expression may be a marker for cancer. Nucleotide polymorphisms may be linked to pre-term labour due to premature rupture of membranes.
References in periodicals archive ?
It is against this background that this study investigated the perinatal outcomes of HIV-positive, compared with HIV-negative women presenting with PPROM at the regional hospital in KwaZulu-Natal Province (KZN), South Africa.
8 Table 2: General Linear Model of Risk Factors for Cesarean Delivery with Subset of Discharges Coded for Labor and PPROM and without Indication for Primary Prelabor Cesarean Delivery Vaginal Cesarean Delivery % Delivery % with Risk with Risk Factor (N = Factor (N = Risk Factor * 7,669,607) 957,483) Age (years) [less than or equal to] 17 4.
She was such a support and through her group I met mothers whose children had survived PPROM and it gave me hope that my baby might too, even though nobody had heard of it happening so early in pregnancy before.
PPROM is defined as a rupture of the amniotic membranes before 37 weeks of gestation and before the onset of labor1-2.
In our study, PPROM could be partially attributed to a relatively higher proportion of polyhydramnios in teenage mothers (3% vs.
Previous research from Murtha and her colleagues demonstrated that the chorion has more cell death when infection is present, and that this cell layer may be thinner in women who experience PPROM.
Various causes have so far been propounded for PPROM - with a sizable bulk of evidence relating it to biochemical processes such as disorders of collagen synthesis in the extra-cellular matrix of amnion and chorion and planned death of cells in fetal tissues.
3) Los fetos afectados por este sindrome presentan compromiso multiorganico, mayor morbilidad y en caso de PPROM son mas propensos a presentar parto pretermino.
We do not have effective methods to prevent PTL or PPROM from resulting in preterm delivery.