PPARG

(redirected from PPARG2)

PPARG

A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, and controls the peroxisomal beta-oxidation pathway of fatty acids. It is a key regulator of adipocyte differentiation and glucose homeostasis.

Molecular pathology
Defects in PPARG mutation are linked to type-2 insulin-resistant diabetes and hypertension, obesity, glioma type 1, and cause familial partial lipodystrophy type 3.

peroxisome proliferator-activated receptor-gamma gene

,

PPARG

A gene with an allele that increases the risk of developing type 2 diabetes mellitus. People with this allele may benefit from treatment with thiazolidinedione drugs.
References in periodicals archive ?
Seven genes (RYR1, ACOX2, PPARG2, MAPRE1, ADAMTS2, MYOM1, and ZDHHC13) are significantly different (p<0.
This study compared methylation differences and expression differences of 12 genes, including TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3PXD2B.
Similar to RYR1, PPARG2 is another gene with exon hypo-methylation.
Several genes were highlighted due to their known association with growth and production, including TGFB3, ACSL1, RYR1, ACOX2, PPARG2, NTN1, RIN2, MAPRE1, ADAMTS2, MYOM1, ZDHHC13, and SH3PXD2B.
Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk.
Effect of the Gly972Arg, SNP43 and Prol2Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatan, Mexico.
Effect of the Gly972Arg, SNP43 and Pro12Ala polymorphisms of the genes IRS1, CAPN10 and PPARG2 on secondary failure to sulphonylurea and metformin in patients with type 2 diabetes in Yucatan, Mexico.
PPARG2 es miembro de la familia de receptores nucleares ligados a factores de actividad transcripcional.
Los polimorfismos Gly972Arg/BstO1 del gen IRS1 y Pro12-Ala/MvaI del gen PPARG2 se identificaron empleando las secuencias de oligonucleotidos y las condiciones de la reaccion en cadena de la polimerasa (PCR) para amplificar el fragmento de interes (5, 23).
Differential expression of two types of PPARG has been reported in several studies: PPARG1 mRNA was expressed to a higher levels compared to PPARG2 mRNA in human adipose tissues (Vidal-Puig et al.
Our study suggests that minor difference of DNA methylation status of PPARG2 and FABP4 promoter may profoundly affect gene expression levels.
PPARG2, a variant of PPARG, contains an amino acid substitution of proline for alanine at codon 12 (Pro12Ala) (6).