PPARG

(redirected from PPARG1)

PPARG

A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, and controls the peroxisomal beta-oxidation pathway of fatty acids. It is a key regulator of adipocyte differentiation and glucose homeostasis.

Molecular pathology
Defects in PPARG mutation are linked to type-2 insulin-resistant diabetes and hypertension, obesity, glioma type 1, and cause familial partial lipodystrophy type 3.

peroxisome proliferator-activated receptor-gamma gene

,

PPARG

A gene with an allele that increases the risk of developing type 2 diabetes mellitus. People with this allele may benefit from treatment with thiazolidinedione drugs.
References in periodicals archive ?
Cos-7 cells were transiently transfected with vectors containing human PPARG1 (provided by V.
Cos7 cells were transfected with human PPARG1 and RXRA expression vectors and a PPRE-driven reporter construct and treated with vehicle or FM550.
A) Cos-7 cells were transiently transfected with human PPARG1 and PPRE x3-TK-luc, with either pcDNA3 or PPAR[gamma]-DN vectors.
In this study, association of DNA methylation levels and PPARG1 and FABP4 gene expression levels were examined in the IMF and muscle portions of the longissimus dorsi muscle (LM) tissues in Korean cattle steers.
To detect expression levels of PPARG1 and FABP4 genes, total RNA was isolated as previously described (Jeong et al.
To determine DNA methylation levels, target regions of PPARG1 (Figure 1a) and FABP4 (Figure 2a) genes were selected from the CpG islands, which were searched using CpG Island Searcher (USC Norris Comprehensive Cancer Center, USA; http://www.
Real-time PCR analysis showed that mRNA levels of both PPARG1 (Figure 1b; p<0.
Next, we determined DNA methylation levels within CpG island promoter regions of the PPARG1 and FABP4 genes.
Two types of PPARG splice variants, PPARG1 and PPARG2, have been identified in several species, including mouse (Zhu et al.
We found that DNA methylation levels of the first two PPARG1 promoter CpG sites (+187, +203) were lower in the IMF portion than those in the muscle portion of steers.
In contrast, the differences of PPARG1 and FABP4 gene expression levels between IMF and muscle portion were about 10 to 100 times (Figure 1c and Figure 2c).