PPARG


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PPARG

A gene on chromosome 3p25 that encodes a member of the nuclear receptor family of ligand-activated transcription factors, which heterodimerise with the retinoic X receptor (RXR) to regulate gene expression. PPARG binds peroxisome proliferators such as hypolipidaemic drugs and fatty acids, and controls the peroxisomal beta-oxidation pathway of fatty acids. It is a key regulator of adipocyte differentiation and glucose homeostasis.

Molecular pathology
Defects in PPARG mutation are linked to type-2 insulin-resistant diabetes and hypertension, obesity, glioma type 1, and cause familial partial lipodystrophy type 3.

peroxisome proliferator-activated receptor-gamma gene

,

PPARG

A gene with an allele that increases the risk of developing type 2 diabetes mellitus. People with this allele may benefit from treatment with thiazolidinedione drugs.
References in periodicals archive ?
Recent reports have also shown that activated LR1H3 stimulates adipocyte differentiation through the induction of PPARG expression (Seo et al.
Activation of PPARG promotes terminal differentiation through the induction of a range of genes important for TG formation through fatty acid oxidation among downstream pathways involving CPT2, ACADL, and ACOX2.
The PPARG is a key adipogenic transcription factor that plays an important role in adipogenesis and fatty acid metabolism.
In conclusion, capsaicin induced apoptosis by activating CASP3 and BAX, and it decreased mRNA expression of adipogenesis-related genes such as PPARG, CEBPA, FABP4, and SCD.
Furthermore, follicular cancers with gene fusions between CREB3L2 (cAMP responsive element binding protein 3-like 2) and PPARG have been described (12), indicating that PAX8 is not the only fusion partner for PPARG.
2] Human genes: PAX8, paired box 8; PPARG, peroxisome proliferator-activated receptor gamma; CREB3L2, cAMP responsive element binding protein 3-like 2.
Two types of PPARG splice variants, PPARG1 and PPARG2, have been identified in several species, including mouse (Zhu et al.
To address these issues, we developed and validated a PAX8/PPARG RT-PCR method and compared its performance with PAX8/PPARG FISH and PPARG IHC methods.
RNA from N-thy-ori 3-1 cells that had been stably transfected with a plasmid containing the PAX8/ PPARG fusion gene (PAX8 exons 1-8 and 10 and PPARG exons 1-6) was used as a positive control.
05), but expression of SCD and mTOR mRNA tended to be depressed in value with the increasing addition of palmitate versus the control, while PPARG mRNA expression had the opposite tendency.
PPARG2, a variant of PPARG, contains an amino acid substitution of proline for alanine at codon 12 (Pro12Ala) (6).
Preneoplastic and neoplastic liver lesions are also associated with PPARG activation.