PPARA


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PPARA

A gene on chromosome 22q12-q13.1 that encodes a ligand-activated transcription factor, which is a key regulator of lipid metabolism. PPARA is a receptor for peroxisome proliferators such as hypolipidaemic
drugs and fatty acids, regulating the peroxisomal beta-oxidation pathway of fatty acids and acting as a transcription activator for ACOX1 and P450. PPARA is upregulated by heterodimerisation with RXRA and downregulated by heterodimerisation with NR2C2.
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Another potential source of SRL pharmacokinetic variability was the rs4253728G>A polymorphism in PPARA.
8] Human genes: ABCB1, ATP-binding cassette, sub-family B (MDR/TAP), member 1; CYP3A, cytochrome P450, family 3, subfamily A; CYP3A4, cytochrome P450, family 3, subfamily A, polypeptide 4; POR, P450 (cytochrome) oxidoreductase; CYP3A5, cytochrome P450, family 3, subfamily 5; PPARA, peroxisome proliferatoractivated receptor alpha.
PPARG, HMGCS2, and CCL2 are all associated with preneoplastic and neoplastic levels in the liver disease progression, and PPARA is additionally associated with neoplastic lesions.