SCN8A

(redirected from PN4)

SCN8A

A gene on chromosome 12q13 that encodes an alpha subunit of the voltage-gated sodium channel, which mediates voltage-dependent sodium ion permeability of excitable membranes. The SCN8A protein product is required for rapid membrane depolarisation, resulting in action potentials in excitable neurones.

Molecular pathology
SCN8A mutations are associated with mental retardation, pancerebellar atrophy and ataxia.
References in periodicals archive ?
In a separate announcement, pursuant to Section 5 of PN4, on 2 July 2001, the Company submitted an application to the Kuala Lumpur Stock Exchange (KLSE) for an extension of time to obtain all the approvals necessary to implement its plan to regularize its financial condition.
On 2 July 2001, the Company submitted an application to the Exchange pursuant to Section 5 of PN4 for an extension of time to obtain all the necessary approvals to implement the plan to regularize its financial position.
Three high-speed USB ports, one type 'A' on the front panel and two ports via the rear PN4 I/O connector, allow for additional memory access options.
A cursory search of the literature reveals that PN1, PN3, and PN4 have been employed.
The VGA interface can be routed on the DVI-I connector or PN4 I/O connector through a video multiplexer.
Again, there were small, transient sex differences with females showing slightly higher values on PN4 (female, 49 [+ or -] 1 fmol/mg protein; male, 43 [+ or -] 1 fmol/mg protein) and PN10 (female, 49 [+ or -] 1 fmol/mg protein; male, 45 [+ or -] 1 fmol/mg protein).
Table 1 shows comparisons among the different biomarkers for control rat brain regions from PN4 through PN60; statistical evaluations were conducted first by repeated-measures ANOVA for the three groupings (cholinergic biomarkers, DNA biomarkers, cell protein biomarkers) and then, as justified by the interactions of development (age) with other variables, by ANOVA across regions for each separate marker, and finally by ANOVA for each region.
0001); forebrain from PN4 to PN21, main effect of sex (p < 0.
The adaptPCI-1PMC card allows data transfers of 32 or 64 bits at up to 66 MHz, and supports PN1 to PN4 connections with 3.
NetBlazer PN1 $2,499 $2,049 NetBlazer PN1 Hub 3,049 2,149 NetBlazer PN2 2,299 1,849 NetBlazer PN2 Hub 2,699 1,949 NetBlazer PN4 2,699 1,949 NetBlazer PN4 Hub 3,099 2,049
Effective immediately, the North American suggested list prices will decrease between $200 and $600 on the following Telebit routers: NetBlazer PN1, NetBlazer PN1 Hub, NetBlazer PN2 Hub, NetBlazer PN4 and NetBlazer PN4 Hub.
Product New Price Previous Price NetBlazer PN1 $2,499 $2,699 NetBlazer PN1 Hub $3,049 $3,399 NetBlazer PN2 Hub $2,699 $2,999 NetBlazer PN4 $2,699 $2,999 NetBlazer PN4 Hub $3,099 $3,699