PLK4

PLK4

A gene on chromosome 4q27-q28 that encodes a member of the CDC5/Polo subfamily of serine/threonine protein kinases. PLK4 plays a central role in centriole duplication and is also involved in trophoblast differentiation by phosphorylating HAND1, which disrupts the HAND1/MDFIC interaction, leading to HAND1 activation. It also phosphorylates CDC25C and CHEK2. PLK4 is downregulated by p53/TP53.
References in periodicals archive ?
The study, entitled "Common variants spanning PLK4 are associated with mitotic-origin aneuploidy in human embryos" can be found online at www.
Today we are excited to announce that we have submitted an Investigational New Drug (IND) application to the Food and Drug Administration for a new drug we have developed based on our research of a target enzyme, PLK4, which plays a crucial role in the process of cell division, particularly in cancer cells.