PLK4

PLK4

A gene on chromosome 4q27-q28 that encodes a member of the CDC5/Polo subfamily of serine/threonine protein kinases. PLK4 plays a central role in centriole duplication and is also involved in trophoblast differentiation by phosphorylating HAND1, which disrupts the HAND1/MDFIC interaction, leading to HAND1 activation. It also phosphorylates CDC25C and CHEK2. PLK4 is downregulated by p53/TP53.
References in periodicals archive ?
They also have demonstrated that an experimental drug, a PLK4 inhibitor, stopped tumour growth.
This is the first time that PLK4 has been described as a therapeutic target for brain tumours or in paediatric cancer,' said lead author Simone T.
Sredni and team were able to identify PLK4 as a potential target for treatment by using a novel gene editing technology called CRISPR/Cas9.
Sredni and colleagues also found that the PLK4 inhibitor (CFI-400945) was safe for normal tissue, while attacking the cancer cells.