PLK2

PLK2

A gene on chromosome 5q12.1-q13.2 that encodes a tumour-suppressor serine/threonine-protein kinase involved in synaptic plasticity and memory, centriole duplication and G1/S-phase transition. PLK2 is induced by p53/TP53, suggesting that it may play a role in mitotic checkpoint following stress. It is highly expressed in foetal lung, kidney, spleen and heart.
References in periodicals archive ?
PCM-075 only targets PLK1 isoform (not PLK2 or PLK3), is oral, and has a 24-hour drug half-life with reversible on-target hematologic toxicities.
The same average myopic shift noted in PLK2 patients should be considered for post-LASIK patients as well.
In contrast, SE20-4, C8FW, and PLK2 showed significance only between the high- and low-TZCA groups.
Among the 9 genes analyzed in human blood samples, the expression of 6 genes, namely, BHLHB2, CCNL1, SE20-4, C8FW, PLK2, and SGK1, was significantly higher in the high-TZCA group than in the low-TZCA group.