PLCG2

PLCG2

A gene on chromosome 16q24.1 that encodes a phospholipase which mediates production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and plays a key role in transmembrane signalling.

Molecular pathology
Defects in PLCG2 cause familial cold autoinflammatory syndrome type 3.
References in periodicals archive ?
Between-placenta variability was higher than within-placenta variability for all genes, except for SYN1, AKT2, and PLCG2 (see Supplemental Material, Table S2).
1 PLCG cascade Time windows BDNF, PLCG1, PLCG2 [beta] (95% CI) p-Value First month of pregnancy -0.