PLCG1

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PLCG1

A gene on chromosome 20q12-q13.1 that encodes a phospholipase which mediates production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and plays an important role in regulating signalling cascades. PLCG1 is activated by ligand-mediated activation of receptor-type tyrosine kinases (e.g., PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4) and plays a role in actin reorganisation and cell migration.
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Lack of PLC1 interferes with normal development and is associated with reduced nephrin and podocin expression.
Professor Marco Falasca, who led the research team, said: "Consistent with these data we detected an increase in PLC1 expression in metastases compared to primary tumours in breast cancer patients.
Subject to the requirements described in the applicable prospectus, the ETNs can be sold in the secondary market during trading hours at market prices, and may typically be redeemed in at least 50,000 units on a daily basis directly to Barclays Bank PLC1.