PIN1


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PIN1

A gene on chromosome 19p13 that encodes an essential peptidylprolyl isomerase, which regulates mitosis by interacting with NIMA and downregulating its mitosis-promoting activity. PIN1 downregulates BTK’s kinase activity, transactivates multiple oncogenes and induces centrosome amplification, chromosome instability and cell transformation. PIN1 is required for efficient dephosphorylation and recycling of RAF1 after mitogen activation.
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The prolyl isomerase Pin1 reveals a mechanism to control p53 functions after genotoxic insults.
Phosphorylation-dependent proline isomerization catalyzed by Pin1 is essential for tumor cell survival and entry into mitosis.
While studying preserved brain tissue from people who had Alzheimer's disease, Lu and his colleagues also found that regions with the highest concentrations of Pin1 had the lowest percentages of nerve cells with tangles.
The animal and human data together create a "strong case" that Pin1 protects against Alzheimer's disease, says D.
In the fourth quarter of 2003, initial testing encompassing over 5,000 patients of specific breast, colon, and lung tumor types using the next generation of Pintex's targeted highly specific antibodies confirmed the co-relationship of Pin1 with other well-known cancer markers, the company said.
In addition, current, extensive animal studies, involving mice at the Arizona Cancer Center, are underway on Pintex's novel family of small-molecule Pin1 inhibitors.
In a recent article in Cancer Research, researchers from Pintex, Harvard Medical School, and Baylor College of Medicine described the Pin1 enzyme as "an independent marker that outperforms many other known and currently used indicators of prostate cancer disease-free survival.
Other co-authors include Kun Ping Lu, a co-discoverer of the Pin1 enzyme and chairman of the Pintex scientific advisory board, and Gerburg Wulf, both of Harvard Medical School; and Gustavo E.
According to the company, the patent effectively ensures that Pintex retains control over any clinically relevant use of a Pin1 antibody, including the development of diagnostic tests and therapies relating to Pin1.
Pintex presently has rights in over 60 patent applications and/or issued patents, and the portfolio is continually expanding, focusing on the Pin1 target.
a Pew scholar at Harvard University, chairman of the Pintex scientific advisory board and co-discoverer of the human Pin1 gene; and Walter Gilbert, Ph.
He added, "We believe that the discovery and elucidation of the Pin1 enzyme and its role in a number of human cancers creates a novel target for discovering new cancer therapeutics.