SPAM1

(redirected from PH-20)

SPAM1

A gene on chromosome 7q31.3 that encodes sperm-adhesion molecule 1 involved in sperm-egg adhesion, which helps sperm penetrate the layer of cumulus cells of an ovum by digesting the hyaluronic acid matrix formed before ovulation.
References in periodicals archive ?
A glycoprotein, PH-20, found on the head of mammalian spermatozoon has hyaluronidase activity and spermatozoa without the PH-20 on their membrane cannot traverse the cumulus cells (Lin et al.