PF4


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PF4

A gene on chromosome 4q12-q21 that encodes a protein released from the alpha-granules of activated platelets which binds with high affinity to heparin. PF4’s major physiologic role appears to be neutralisation of heparin-like molecules on the endothelial surface of blood vessels, inhibiting antithrombin-III activity and promoting coagulation; as a chemoattractant for neutrophils and fibroblasts, PF4 likely plays a role in inflammation and wound repair.
References in periodicals archive ?
Measurements of plasma levels of PF 4 have been shown to be the marker of platelet degranulation and increased level of PF4 is used to detect platelet activation of the circulating pool of platelets [35].
In conclusion, this report is the first to reveal that ICs containing TSP-1 or PF4 are present specifically in the serum of RA patients, and these ICs may have po tential as alternative biomarkers for the diagnosis of RA.
To determine if your patient has HIT, a PF4 antibody must be checked.
Ultralarge complexes of PF4 and heparin are central to the pathogenesis of heparin-induced thrombocytopenia.
Assays used were as follows: TBP (endogenous control), Hs99999910_m1; CXCL16, Hs00222859_m1; IL4R, Hs00166237_m1; JUN, Hs00277190_s1; PF4, Hs00427220_g1; PTPRE, Hs00369944_m1; ZNF331, Hs00367929_m1.
0 U/mL, heparin displaces PF4 from endothelial heparan sulfate or releases it directly from the platelets.
Plasma FDP, FS Test, Asserachrom[R] series (ELISA assays) for HPIA (Heparin Platelet Factor 4 Induced Antibodies), tPA, PF4, b-TG, Protein S (Free & Total), vWF, Protein C, Factor IX: Ag
In HIT, heparin and PF4 form a complex on the platelet surface to which the Fab portion binds.
Maione and their co-workers transplanted mouse melanoma cells and human colon carcinoma cells into mice, then compared tumor growth in mice that did and did not receive daily PF4 injections.