PDGFA


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PDGFA

A gene on chromosome 7p22 that encodes platelet-derived growth factor alpha, which plays a key role in regulating embryonic development and in cell proliferation, migration, survival and chemotaxis. It is mitogenic for mesenchymal cells and required for normal lung alveolar septation during embryogenesis, normal GI tract, Leydig cell and oligodendrocyte development, as well as normal spermatogenesis and myelination in the spinal cord and cerebellum. It plays a key role in wound healing.
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beta 1L10 Interleukin 10 NFKBIA Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha NOTCH1 Notch 1 PDGFA Platelet-derived growth factor alpha polypeptide TNFSF10 Tumor necrosis factor (ligand) superfamily, member 10 VECFA Vascular endothelial growth factor A Category Function Fold change (NF3/control) TCF-[beta]family Apoptosis 6.
Imatinib (Gleevec, Novartis Pharmaceuticals, NJ), which functions by inhibiting and blocking the function of KIT and PDGFA, may achieve an 80% response in KIT exon 11 mutation but only a 50% response in KIT exon 9 mutation.