PDE5A

PDE5A

A gene on chromosome 4q27 that encodes a cyclic nucleotide phosphodiesterase which hydrolyses cGMP to 5'-GMP, resulting in cardiac smooth muscle relaxation.
References in periodicals archive ?
CACNA1D, EDNRA, KCNG2, NR3C2, PDE4D, ACE, ADRA1B, ADRB3, KCNJ11, ADRAJD Cardiac dilation Imipramine EPO, NOS1 Pulmonary hypertension EtOH-Fr EDNRB, FTGER3, PDE5A Pulmonary hypertension Imipramine EPO, EDNRB, FLT3, ABL1, EDNRA, ADRA1B, ADRB3, ADRA1D Increased levels of alkaline EtOH-Fr VEGFA phosphatase Bold indicate that these genes are prevalent in several disease clusters.
He and his team has already shown in 2005 that Viagra's ability to block PDE5A is responsible for blunting hypertrophy due to high blood pressure in mice and offsetting similar, adrenaline-stimulated heart stress in people.