PDE4B


Also found in: Acronyms.

PDE4B

A gene on chromosome 1q31 that encodes a cyclic AMP-specific nucleotide phosphodiesterase, which plays a critical role in signal transduction by hydrolysing the second messenger cAMP to AMP, thereby playing a role in regulating physiological processes.

Molecular pathology
PDE4B alterations have been anecdotally linked to schizophrenia and bipolar disorder.
References in periodicals archive ?
Since PDE4B is expressed by lung cells, we sought to determine whether inhibiting PDE4B decreased fluid accumulation during ARDS.
Two other genes--dubbed PDE4B and PKC-beta--are more active in patients in whom the lymphoma is ultimately fatal than in the other group, the researchers report.
The microarray analysis revealed significant differences in activity of NOR1, PDE4B, and PKC-beta between the two patient groups.