PDE4A

PDE4A

A gene on chromosome 19p13.2 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing the second messenger cAMP to AMP, thereby having a role in regulating physiological processes.
References in periodicals archive ?
sup][17],[21],[22] The PDE4A and PDE4B null mice have been backcrossed from the mixed 129/Ola x C57Bl/6 to the pure C57BL/6 background for at least 12 generations, whereas the PDE4D mice were kept in the mixed background because the PDE4D null mice become embryonic lethal when the null allele is transferred to the pure C57Bl/6 background.
Additionally, rolipram had no significant effects in the PDE4B[sup]−/− cells [Figure 4]b, indicating that pharmacological inhibition of PDE4A and PDE4D in the PDE4B[sup]−/− macrophages has little or no effect on LPS-induced CCL3 production.
Recently, authors suggested a relative selectivity of imperatorin as inhibitor within the PDE4 family, mainly for PDE4A and PDE4B (Ivey et al.