PDE4A

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PDE4A

A gene on chromosome 19p13.2 that encodes a cyclic nucleotide phosphodiesterase, which plays a critical role in signal transduction, regulating intracellular cyclic nucleotide concentrations by hydrolysing the second messenger cAMP to AMP, thereby having a role in regulating physiological processes.
References in periodicals archive ?
Eisai ) on an agreement to license its product E6005 (a selective PDE4 inhibitor) to Roivant Sciences Ltd.
In pre-clinical models of CF, RPL554 was shown to have CFTR-stimulatory properties and that CFTR activation by RPL554 is mediated by its inhibition of PDE4 in cells from CF patients with the R117H/F508del mutation.
In addition, we compared the signaling events that are measured in wildtype to PDE4 isoform specific KO cells to determine the role of each PDE4 isoform in regulating localized cAMP signals in cells.
Its active component, roflumilast, is a potent and selective inhibitor of the PDE4 enzyme.
TM)](aclidinium bromide inhalation powder), a twice-daily long-acting muscarinic antagonist (LAMA) for chronic obstructive pulmonary disease (COPD), and Daliresp (roflumilast), the only once-daily oral PDE4 inhibitor currently on the market for COPD.
Additionally, AstraZeneca will own the development and commercial rights in the US and Canada Daliresp (roflumilast), the only once-daily oral PDE4 inhibitor currently on the market for COPD.
The researchers hypothesized that PDE4 has a stimulatory effect on pancreatic cancer: by hydrolyzing cAMP, PDE4 decreases protein kinase A (PKA) activity, which in turn decreases down-regulation of the SHH pathway, resulting in stimulation of prostate cancer.
In this study, the researchers methodically traced out the metabolic activity in cells treated with resveratrol and identified PDE4 in the skeletal muscle as the principal target for the health benefits of resveratrol.
Knowing that drugs called PDE4 inhibitors werebeing tested to treat Alzheimer's, the researchers gave one such drug, called rolipram, to mice.
Apremilast is designed to modulate the immune system by inhibiting multiple pro-inflammatory cell types by inhibiting a protein known as PDE4.
Evidence indicates that theophylline can produce some degree of immunomodulation, and an antiinflammatory and bronchoprotective effect through inhibition of cAMP-specific phosphodiesterase enzymes, particularly PDE3 and PDE4, in proinflammatory cells and tissues which is discussed below.
A number of studies have been conducted using the PDE4 inhibitors for patients with asthma.