Three isolates had serotypes included in PCV7
, whereas nine isolates did not.
Soon after introduction of PCV7
, serotype 9V IPD became rare (1,2), and 19A became the predominant representative of the ST156 lineage within ABCs (14,32).
9% reduction in antibiotic prescriptions for AOM was demonstrated from 1997 to 2004 following implementation of the PCV7
However, after wide application of PCV7
, "serotype replacement", a phenomenon that PCV7
serotypes decreased with concurrent increase of NVTs among invasive and noninvasive diseases was observed.
000) Las tasas de enfermedad en pacientes expuestos a vacunacion con PCV7
podemos encontrarlas en la tabla 1.
However, the antibody responses and safety profile observed in this trial are similar to those observed in other trials comparing PCV13 with PCV7
2/100,000 between 1998 and 2007--most likely because routine use of the PCV7
vaccine in children has resulted in decreased carriage and transmission of infection from children to adults.
was introduced in the infant immunisation programme in the USA in 2000.
Before the introduction of PCV7
, regional variations in the prevalence of antibiotic resistance were considered to be caused by regional differences in antibiotic use, leading to differences in the intensity of selective pressure acting on the bacterial population (9).
2) suggested that the increasing trend in empyema was also present before PCV7
introduction; for this reason, a direct association with the PCV7
vaccination program is unlikely.
Children were classified into in 3 groups: i) those born in the period January 1, 1994 to April 30, 1997 and targeted by the 2002 mass campaign with PPSV23; ii) those born in the period May 1, 1997 to March 31, 2002 and targeted by the PCV7
catch-up campaign initiated in the spring of 2002; and iii) those born in the period April 1, 2002 to December 31, 2005 and targeted by the PCV7
routine infant program.
When the levels of immunity were measured against multiple childhood illnesses, the researchers found that the children who had received the PCV13 had no less or weaker immune response than the children who had received the PCV7