KAT2B

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KAT2B

A gene on chromosome 3p24 that encodes a ubiquitously expressed enzyme which has significant acetyltransferase activity with core histones (H3 and H4) and nucleosome core particles. KAT2B inhibits cell cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. It is recruited by HIV-1’s Tat protein; it may regulate its transactivating activity and help induce chromatin remodelling of proviral genes. KAT2B is most abundant in the heart and in skeletal muscle.
References in periodicals archive ?
Transient transfection followed by immunoblotting identified HDAC2 and PCAF as the key enzymes involved in controlling H3K9 acetylation status (Figure 2C,D).
Analysis of PCAF expression at the 3-hr time point revealed a significant increase in PCAF expression; however, at the 72-hr exposure, PCAF expression was suppressed at both tolerated and toxic doses (Figure 2F).
In 10 years, PCAF has established eight trauma clinics: two in Cambodia, four in Uganda, one in Liberia and one in a maternal child health clinic in one of Africa's largest slums in Kibera, Kenya and treated more than 100,000 patients.
Case managers completed a 7-day 24-hour flow sheet that identified the PCS hours needed by a child, based on information obtained during the assessment with the PCAF.
As at 31 May 2011 PCAF had holdings in 33 hedge funds across twelve different strategies.
PCAF staff continues to treat the refugees that remain in Uganda to this day.
A viral mechanism for inhibition of p300 and PCAF acetyltransferase activity.
Fauchier Allocator Funds I and II and, from 1 June 2010, PCAF.
Using this approach, we found that HER2, MMP7, and PCAF may be down-regulated during distal dissemination of colorectal tumors.
Targeting PCAF -- the host cell protein -- rather than the HIV cell protein as a strategy to block HIV gene expression has several advantages," Dr.
The clinic opening also marks the opportunity for the PCAF to operate on the frontlines of post-conflict regions and at the same time gather data on the treatment of highly traumatized Ugandans.
We are so pleased that PCAF has joined us in our commitment to overall breast health for all women," said Kevin Fox, M.