PBX1


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PBX1

A gene on chromosome 1q23 that encodes a nuclear protein belonging to the PBX homeobox family of transcriptional factors, which regulates osteogenesis and is required for skeletal patterning and programming.
 
Molecular pathology 
A translocation t(1;19) involving PBX1 and TCF3/E2A is associated with acute pre-B-cell lymphoblastic leukaemia; the resulting fusion protein, in which the DNA-binding domain of E2A is replaced by the PBX1 DNA-binding domain, upregulates gene transcription.
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Department of Defense (DoD) PBX1 certification for Polycom IP Phones with the Sphere Communications Sphericall IP PBX.
The DoD's Joint Interoperability Test Command (JITC) PBX1 certification is required for DoD organizations to deploy Polycom IP phones with Sphericall IP PBX in mission-critical Command and Control environments, and deliver assured connectivity across multiple Assured Services Voice Application Local Area Networks.
We are excited to team with Sphere Communications to support JITC PBX1 certification," said Sunil Bhalla, senior vice president and general manager, voice communications, Polycom.
We believe that DoD and civilian organizations alike gain incredible value through the PBX1 certification," said Graeme Robinson, president, Sphere Communications.
The DoD's PBX1 testing is second to none-any organization considering IP PBX deployment should demand this level of validation," announced Chuck Pearson, Chairman and CEO, Sphere Communications.
JITC PBX1 requirements, established by the Defense Information Systems Agency, cover secure PBX operation, with no performance degradation, over multi-vendor data networks.
Sphere Communications included products from Aastra Technologies, Allied Telesis and Polycom in its PBX1 certification.
Cisco Becomes First Vendor to Achieve JITC PBX1 Interoperability, Reliability, Resilience and Security Certification with IP-centric Softswitch
Cisco's new Joint Interoperability Test Command (JITC) PBX1 certification allows DoD organizations to deploy the Cisco IP Communications system in mission-critical environments such as Command and Control Voice-Grade Local Area Networks (C2VGLAN).
The certification makes Cisco the first vendor to achieve PBX1 certification with an IP-centric softswitch.
Cisco's PBX1 certification allows government agencies to start moving away from legacy TDM (Time Division Multiplexing) switches and take advantage of the tremendous flexibility of VoIP," said Brad Curran, defense communications analyst at Frost & Sullivan.
Cisco is now working toward PBX1 certification, which would allow DoD organizations to migrate Command and Control users to the same Cisco infrastructure.