PBPK


Also found in: Acronyms.

PBPK

physiologically-based pharmacokinetics.
References in periodicals archive ?
The PBPK model structure for dichloromethane traces back to one originally developed by Gargas et al.
Important and extensive research has been conducted over the last 15 years to address many of these uncertainties and it is anticipated that the development of PBPK models will also permit for the reduction of these uncertainties and permit for the application of chemical-specific adjustment factors (CSAFs), greatly improving risk assessments for Mn.
PBPK modeling as a basis for achieving a steady BrAC of 60 +/- 5 mg% within ten minutes.
2013), and there are few chemicals for which sufficient individual human toxicokinetic data are available to conduct population PBPK modeling.
Describing the principles, methods, and applications of PBPK modeling as used in pharmaceutics, Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations fills this void.
Two outliers were dichloromethane and trichloroethylene and the difference was largely due to the use of PBPK model-based dosimetry in the original assessments.
The role of metabolism in toxicity, informed by the development and application of an updated PBPK model
For example, this means broader capabilities to predict drug disposition as a function of molecular structure, and the ability to utilize a single unified suite of tools to facilitate preclinical and clinical PBPK and PKPD modeling and analysis.
2013) one should take into account that PBPK models, although useful, are based on many assumptions.
This appointment further enhances the specialist team within Simcyp and strengthens the company's ongoing scientific expansion, particularly in the development of PBPK models for biologics.
The rapid expansion, guided by the priorities set by the industry, has made the Simcyp Simulator a unique, globally-recognised and trusted PBPK tool for performing virtual clinical trials before deciding on the conduct of actual studies.