PAX8

PAX8

A protein product of one of the PAX family of genes. It is used clinically as a biomarker of follicular thyroid cancer.
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PAX8 has been shown to be an excellent distinguishing marker between ovarian and breast carcinoma, as it is positive in nearly all ovarian carcinoma stains and is negative in breast cancer stains (10, 11).
Molecular findings have shown rearrangements of the peroxisome proliferator-activated receptor gamma (PPAR[gamma]) gene in as many as 50% of follicular carcinomas, which results in a fusion between the PAX8 gene on 2q13 and the PPARy gene on 3p25.
PAX8 is known to play a critical role in FT organogenesis and as we have shown it is highly conserved in HGSC.
Abbreviations: FOXC1, forkhead box C1; H3K27me3, H3K27 trimethylation; miRNAs, microRNAs; PAX8, paired box gene 8; PRC2, polycomb repressive complex 2; PSP94, prostate secretory protein of 94 amino acids; Rap1, Ras-proximate-1 or Ras-related protein 1; Rap1GAP, Rap1 GTPase-activating protein; RKIP, Raf-1 kinase inhibitor protein; RUNX3, Runt-related transcription factor 3 gene.
Specifically, the SLITRK1 gene is associated with Tourette's syndrome, and the PAX8 gene is linked to hypothyroidism.
Specifically, the SLITRKI gene is associated with Tourette's syndrome, and the PAX8 gene is linked to hypothyroidism.
Biocare's portfolio of immunohistochemistry (IHC) and molecular pathology products includes a wide array of primary antibodies like p63, ERG and a monoclonal PAX8, as well as kits used by hospitals, reference and research laboratories worldwide.
A similar fraction of follicular carcinomas, but a much smaller fraction of adenomas, are found to harbor a t(2;3)(q13; p25) chromosomal translocation that fuses the PAX8 [2] (paired box 8) gene with the PPARG (peroxisome proliferator-activated receptor gamma) gene (2).
TTF1 and PAX8 are implicated in proliferation and survival of thyroid cell precursors, and TTF2 plays a role in migration and proliferation of thyroid precursors.
The tumour was labelled for cathepsin K and melan A and focally for HMB45, while rare cells were labelled for EMA, PAX8, Cam5.
The tumor cells were immunohistochemically reactive for RCC antigen, CD10, CK903, P504-S (AMACR), and PAX8.
The PAX8/PPARG rearrangement is created by a somatic genetic translocation between chromosome arms 2q and 3p, in which the entire coding region of the PPARG transcription factor gene is fused in frame with the first 8 to 10 exons of the PAX8 gene, which encodes a thyroid-specific paired box transcription factor (6).