PAX2

PAX2

A gene on 10q24 that encodes a human homologue of Drosophila melanogaster gene prd. This family of transcription factor genes have a conserved DNA-binding paired box domain. PAX2 is thought to be a target of transcriptional suppression by the tumour suppressor gene WT1.

Molecular pathology
PAX2 mutations cause optic nerve colobomas and renal hypoplasia. PAX2 distinguishes benign mesonephric and mullerian glandular lesions of the cervix from endocervical adenocarcinoma, including minimal deviation adenocarcinoma.
References in periodicals archive ?
From compact CUB indicators to versatile PAX2 process meters, Red Lion provides flexibility that allows customers to seamlessly add or change capabilities with plug-and-play field installable option cards.
These entities can also be positive for PAX2, kidney-specific cadherin, carbonic anhydrase IX, and parvalbumin (3).
The investigators were able to differentiate both human ES cells and human iPS cells into cells expressing PAX2 and LHX1, two key markers of the intermediate mesoderm.
Renal coloboma syndrome is inherited autosomal dominantly and PAX2 is the only gene known to be associated with RCS (4).
They identified a regulatory molecule called PAX2 that helps tamoxifen work by switching off a cancerpromoting gene.
Carroll said developing tests that doctors can use on a regular basis to determine if women have low levels of the protein, called PAX2, or high levels of a competing protein, known as AIB-1, are still at least five years away.
Scientists identified a regulatory molecule called PAX2 that helps tamoxifen work by switching off a cancer-promoting gene.
PAX2 and PAX8 staining were also negative which helped rule out a malignancy of kidney origin.
12"- PACH3 General Tommy Franks AX MXJ MJB MXPG, MXP8, MJP12, MJPC, PAX2, XF, NFP ("Tommy"), a Parson Russell Terrier owned by Cherie Whittenberg and handled by Deva Wilson
66) Among the carcinoma markers, PAX8 or PAX2 are the most useful as they are expressed in most renal cell carcinomas (Figure 18), (67) but not in mesotheliomas.
Newest Addition to PAX2 Series Improves Flexibility and Ease of Use for Process & Temperature Control Markets