PARP


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PARP

Poly(ADP-ribose) polymerase. Any of a group of enzymes (five have been identified—PARP1–5) whose prototypic member (PARP1) is encoded by PARP1 on chromosome 1q41-q42. PARP1 detects and repairs single strand breaks in chromosomal DNA, and plays a key role in initiating DNA repair. High levels of PARP1 are associated with increased apoptosis in response to genotoxic stress, and it may act downstream of the Raf-MEK-ERK pathway through direct interaction with ERK2 in the nucleus, repairing DNA damage. PARP inhibitors are being explored as therapies for cancer, diabetes, stroke and cardiovascular disease.
References in periodicals archive ?
Synergistic combination of PM1183 and PARP inhibitors in breast cancer tumor cell lines(Abstract #2520).
Speaking to Reuters in a telephone interview she said the identification of RAD51D pointed to PARP inhibitors as a new class of drugs that might offer fresh hope.
PARP inhibitors are also said to be effective against cancer cells that are low in oxygen, which include many fast-growing tumors.
Therefore, inhibition of PARP can prevent the repair of single strand DNA breaks, which in turn causes double strand DNA breaks and ultimately leads to cancer cell death.
It showed that 60% of all women with ovarian cancer might benefit from PARP inhibitors.
It may become important to identify women with these mutations because the mutation provides a rational target for treatment with PARP inhibitors - a class of drugs currently under development," said Dr.
BiPar's lead product candidate is BSI-201, a potential first-in-class PARP inhibitor currently being studied in Phase 2 clinical trials in metastatic triple negative breast cancer (TNBC), ovarian cancer and other malignancies.
But instead of giving him a punishing essay to write about the Ancient Egyptians, Kristina bought him a whoopee cushion, turning the place into King Butt's Parp Parp Hut.
based gaggle called the Brotherhood Organization of a New Destiny that's anti-PUSH and, our favorites, the PARP.
Under an agreement between the companies, NewGen has received exclusive global rights, excluding China, for the development, manufacture and commercialization of three separate small molecule therapeutic programs targeting pan-ErbB, EGFR/Her-2, and PARP, respectively.
e Medical Schools Council has published its Health of the Nation study, which reports the very best medical research happening across the UK, and highlights Newcastle University's breakthrough in the development of "smart" drugs known as PARP inhibitors.
PARP inhibitors are currently in clinical trials for the treatment of certain breast and ovarian cancers as well as other solid tumors.