PARP


Also found in: Dictionary, Acronyms, Wikipedia.

PARP

Poly(ADP-ribose) polymerase. Any of a group of enzymes (five have been identified—PARP1–5) whose prototypic member (PARP1) is encoded by PARP1 on chromosome 1q41-q42. PARP1 detects and repairs single strand breaks in chromosomal DNA, and plays a key role in initiating DNA repair. High levels of PARP1 are associated with increased apoptosis in response to genotoxic stress, and it may act downstream of the Raf-MEK-ERK pathway through direct interaction with ERK2 in the nucleus, repairing DNA damage. PARP inhibitors are being explored as therapies for cancer, diabetes, stroke and cardiovascular disease.
References in periodicals archive ?
The exact mechanism through which PARP inhibitors function is not fully understood; however, four models currently exist to explain how PARP inhibitors instigate synthetic lethality.
One such commercially available companion diagnostic test is paired with AstraZeneca's drug Lynparza (olaparib), which is a PARP inhibitor.
The PARP went to court to stop the sale, going as far as the Supreme Court.
In this investigation, we identified, characterized, and assigned a possible function for a cytoplasmic PARP in the CNS of Octopus vulgaris.
PARP inhibitors are also said to be effective against cancer cells that are low in oxygen, which include many fast-growing tumors.
It showed that 60% of all women with ovarian cancer might benefit from PARP inhibitors.
Basically PARP-inhibiting drugs block PARP from compensating for the loss of BRCA function and from repairing DNA damage.
BiPar's lead product candidate is BSI-201, a potential first-in-class PARP inhibitor currently being studied in Phase 2 clinical trials in metastatic triple negative breast cancer (TNBC), ovarian cancer and other malignancies.
One company has developed an orally bioavailable PARP inhibitor that crosses the blood-brain barrier that will be used as a chemotherapeutic agent (MGI Pharma, n.
But instead of giving him a punishing essay to write about the Ancient Egyptians, Kristina bought him a whoopee cushion, turning the place into King Butt's Parp Parp Hut.
We wish to direct readers to two items about PARP published in the October and December 2004 issues of UpHere magazine, published in Yellowknife.