NLRP2

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NLRP2

A gene located on chromosome 19q13.42 that encodes a NLRP2 (i.e., NALP2), a pyrin-like protein involved in activating caspase-1 (CASP1) by Toll-like receptors. NALP2 suppresses TNF- and CD40-induced NFKB1 activity at the IKK complex by inhibiting TNF-induced NFKBIA degradation. When associated with PYCARD, NALP2 activates CASP1, leading to the secretion of the pro-inflammatory cytokine IL1B.
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References in periodicals archive ?
However, because of the introduction of PAN1 into the polymer network, PAA-g-PEG/PAN1 shows a higher conductivity (11.
Studies on the development and application of nanotechnology in preparing PAN I explored a wider range of application prospects for PAN1.
Olgun coworkers (9), (10) have studied the PAN1 blending with chlorine-containing polymer and copolymers, and their radiation response in terms of induced conductivity.
On the other hand, when PAN1 is reduced to the leucoemeraldine base (LEB) form, all the quinoid structures are converted to benzoid, leading to fully extended and linear conformation of the chains (27), (28).