PAK4

A gene on chromosome 19q13.2 that encodes a PAK protein of the serine/threonine p21-activating kinase family, which serve as targets for the small GTP-binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases; it mediates filopodia formation and may play a role in reorganising the actin cytoskeleton.

References in periodicals archive ?

SH3RF2 functions as an oncogene by mediating PAK4 protein stability.

Functional analysis of SH3 domain containing ring finger 2 during the myogenic differentiation of quail myoblast cells

PAK4 confers cisplatin resistance in gastric cancer cells via PI3K/Akt- and MEK/Erk-dependent pathways.

G-protein Coupled Receptor 34 Knockdown Impairs the Proliferation and Migration of HGC-27 Gastric Cancer Cells In Vitro

Here neurologists and other biomedical researchers explain in some detail how PAKs--particularly the oncogenic kinases PAK1 and PAK4 and their blockers--may control various aspects of life and health, and how mammalian PAKs have functionally evolved from their ancestral origins in unicellular organisms such as yeast and amoebas through a series of mutations over millions of years.

PAKs, RAC/CDC42 (p21)-activated kinases; toward the cure of cancer and other PAK-dependent diseases

53-57) For example, novel candidate oncogenes include SMURF1 on 7q21, FGFR1 on 8p12, BIRC2 and BIRC3 on 11q22, and PAK4 on 19q13, whereas novel candidate tumor suppressor genes include TUSC3 on 8p22 and FEZ1 on 8p23.

The pathology and genetics of metastatic pancreatic cancer

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