PAK2


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PAK2

A gene on chromosome 3q29 that encodes a PAK protein of the serine/threonine p21-activating kinase family, which serve as targets for the small GTP-binding proteins Cdc42 and RAC and have been implicated in a wide range of biological activities. PAK2 is activated by proteolytic cleavage during caspase-mediated apoptosis, and may play a role in regulating apoptosis.
References in periodicals archive ?
68-70] residues near to PQVPLR, also have been suggested to be necessary for Nef/ activated PAK2 complex formation and MHC-I downregulation (45).
Nef[DELTA]12 (residues 1-65) only has the myristoylation (MIR) domain; 2c Nef[DELTA]14 (residues 20-94) contain Proline-rich Sequence (SH3 binding domain) and the first Arg-rich sequence (PAK2 binding domain); 2d Nef[DELTA]36 (residues 91-143) contain SH3 binding domain, the first PAK2 binding domain and dimerization dimerization (DIM), and absence of c-terminal portion and 2e Nef[DELTA]38 (residues 91-206) contain SH3 binding domain, the both PAK2 binding domain, dimerization (DIM), c-terminal portion, but absence of the myristoylation (MIR) domain.
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2," Science, Vol.