PAI-1


Also found in: Acronyms.

PAI-1

SERPINE1

A gene on chromosome 7q21.3-q22 that encodes a serine protease inhibitor that acts on tissue plasminogen activator (tPA) and urokinase, inhibiting fibrinolysis.

Molecular pathology
SERPINE1 mutations cause plasminogen activator inhibitor-1 deficiency; high concentrations of the gene product are associated with thrombophilia.

PAI-1

Abbreviation for plasminogen activator inhibitor-1.
References in periodicals archive ?
TaqMan PCR analyses for PAI-1 and tPA were performed using predeveloped and commercially available primers and probe sets (cat.
The aliquots were removed after 24 h incubation and were frozen immediately at -80[degrees]C for later measurement of t-PA and PAI-1 (see below).
Of women with high concentrations of uPA and PAI-1 who got chemotherapy, about 12 percent relapsed, Prechtl reports.
In the women, TPA levels were up 20 percent, but PAI-1 levels were unchanged, the study said.
Co-author Steven Shea, PhD, director of the Oregon Institute of Occupational Health Sciences, sad that their findings indicate that the human circadian system causes a morning peak in circulating levels of PAI-1, independent of any behavioral or environmental influences.
A positive correlation between PAI-1 experssion and pulmonary metastatic potential in human fibrosarcoma cells (HT1080 and HT1080-P4) has also been reported (Matsuda et al.
The change in absorbance at 950 nm produced by latex agglutination was monitored over 10 min, and the concentration of PAI-1 in the sample was calculated from the calibration curve.
A total of 242 patients were deemed to be at high risk due to a tumor uPA and/or PAI-1 above this threshold; they were randomized to either observation only or combination chemotherapy.
The enzymes uPA and PAI-1 are instrumental in tumor invasion and angiogenesis.
Sobel said in an interview that the body's allotment of PAI-1 apparently is saturated with tPA during treatment, but then exerts its inhibitory effects in some patients after tPA infusion stops.